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Specifically, we found that GSSG elevation suppressed the phosphorylation/activation of IKK-, a proximal kinase in the NF-B signaling pathway that phosphorylates IB-, leading to its proteasomal degradation and subsequent NF-B activation

106,107 Hence, it is challenging to attribute the renal effects of DPP4 inhibitors solely to glucose reduction in in vivo trials

It consists of three amino acids, has a small molecular weight, and can cross the blood-brain barrier orally

Western blot analyses Cells were lysed in ice-cold RIPA buffer (GenDEPOT) for 10 min on ice

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